Rheumnow Podcast

Dr Juliana Simonetti 7 Dr. Philip Mease 'What Are the Four Pillars of Obesity Management?': https://youtu.be/TwhlkRtsjtA

Dr. Richard Conway Bariatric Surgery 'Curing' Arthritis?: https://youtu.be/W2-0RkyGqcc
Dr. David Liew Managing Muscle and Fat Loss with GLP-1s: https://youtu.be/fLCDLuJGyPA
Daric Mueller (PA-C) GLP-1s and History of Thyroid Cancer?:https://youtu.be/H_UlthPGN6Y
Dr. Bella Mehta How Weight Loss Changes the Course of Knee Osteoarthritis: https://youtu.be/Jg0hflvIMEo

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com

Dr. Antoni Chan The Weight Behind the Delay in Diagnosis: https://youtu.be/-gxaFidWRw0 
Dr. Mrinalini Dey Obesity: Escalate or Reassess?: https://youtu.be/Y6f_Qt5snMI
Dr. Michael Putman Managing Obesity: By PCP or Rheumatologist?: https://youtu.be/zASyKJECfiM

Explore the complex relationship between obesity, inflammation, and rheumatic disease—and how excess adiposity may influence disease development, severity, treatment response, and patient outcomes.

In this expert-led discussion, leading clinicians and researchers examine how obesity can accelerate inflammatory and autoimmune rheumatic disease through metabolic, biomechanical, and immunologic pathways.

The panel explores the biology of adipose tissue and its role in systemic inflammation, including how obesity affects disease risk and progression, response to rheumatologic therapies, and the potential for weight loss and other interventions to reduce inflammation and improve clinical outcomes.

Expert Faculty:
• Juliana Simonetti, MD
• Lihi Eder, MD, PhD
• Naveed Sattar, MD, PhD
• Lee Kaplan, MD, PhD
• Jack Cush, MD — Moderator

Dr. Jack Cush reviews the news and journal reports from this past week on Rheumnow.com - including obesity, disappointing durability with GLP-1 drugs, AI diagnoses and worries about CV risk in ANCA-associated vasculitis.

The Obesity Journal Club explores the TOGETHER PsA and STEP 9 trials and what emerging evidence tells us about the relationship between obesity, weight loss, and rheumatic disease. Authors of the papers and experts will discuss the results of these trials, discuss how we consider obesity as both a comorbidity and part of the disease course, and share practical strategies for addressing obesity in everyday rheumatology practice.
Speakers: Dr. Philip Mease Dr. Tom Appleton Dr. Jack Cush (moderator)

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.  New drugs approved, new drugs halted and some drugs out of control.

Join Amanda Mixon, PA-C, for a practical look at the role of the rheumatology advanced practice provider (APP) in recognizing and managing interstitial lung disease (ILD).

Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc.

The Derm on RheumNow podcast is a review of recent citations and content curated for dermatologists – addressing Psoriasis, PsA, CLE, vasculitis, HS, CTD skin disorders. dermatology drugs, biologics, andJAK inhibitors - their use, efficacy and side effects.

Features Dr. Jack Cush, Editor at RheumNow.com.

Show Notes:
Latest #s: EHR estimates from 6 large US medical systems, estimated prevalence of autoimmune Dz (AID) to be 15 million (4.6% US population); 34% have 2+ AID. Women have 2x risk. Sex ratio of 1.7:1 F:M. https://buff.ly/fYgRfZ0

POETYK PsA-1: Deucravacitinib in Biologic-Naïve PsA POETYK PsA-1 trial tested the disease modifying efficacy of deucravacitinib, a tyrosine kinase 2 (TYK2) inhibitor, in PsA patients and was shown to be superior vs to placebo for clinical responses, patient-reported outcomes, https://t.co/VjwpCVKPz0

MoonLake announced positive phase 3 data from its IZAR-1 RCT using its dual A/F IL-17 inhibitor sonelokimab, showing significant responses at week 16: 66% ACR20, 42% ACR50, 41% minimal disease activity (MDA), & 61% PASI90 at week 16. a 2nd IZAR-2 PsA RCT is in progress https://t.co/eX0cxekRKG

British Dermatology Biologics registry (BADBIR) 18976 #PSO pts had incidence serious infxns (SIE) 28 SEI/1000 Pt-Yrs; higher if they had prior infxn (79/1000 PYs). SIE signif lower w/ RIZankizumab (HR 0.74-.80) vs BROAD, ETN, other standards Rxs. SIE deaths rare (1.81/1000 PYs) https://t.co/GTr3DLCVXs

39 studies compared Juvenile systemic sclerosis (jSSc) & adult SSc. 935 jSSc vs 15,451 aSSc pts; jSSc had more diffuse cutaneous dz (70% vs 41%), more overlap myositis (33% vs. 5%), arthritis (33% vs 18%), digital ulcers (51% vs 20%), less renal crisis (0% vs 6%) & lower mortality jSSc (7.7% vs. 20.4%) https://t.co/vflarmwSyv

Italian SPRING cohort of #SSc pts found only 5.3% (of 1689 pts) without the typical scleroderma pattern on nailfold change by NVC. They had milder dz, with less vascular dz (pitting scars 33 vs 48%), telangiectasias (52 vs 74%), calcinosis 3.4 vs 12%) & higher DLCOs at 12, 24, https://t.co/AoNAhVYfII

Review of CAR-T 29 trials in systemic sclerosis (SSc): 27/29 target CD19 (other CD20, BCMA), 20/29 autologous. Only 2 RCTs; 1 w/ RTX comparator. Most included CREST. Schetts largest series had 6 dcSSc w/ skin/lung improvements. Need fewer & larger multicenter RCTs https://t.co/Me28HbaFhR

SLE & Dermatomyositis rashes maybe classically red or violaceous in Whites,but different in people of color, where erythema often appears brown/violaceous, Gottron papules can be mistaken for "dry skin." This delays dx, especially in anti-MDA5+ RP-ILD, where rash may be the https://t.co/Savx5IOTcG

Yesterday the EMA approved upadacitinib (Rinvoq) for the Treatment of Adults and Adolescents with Non-Segmental Vitiligo - the 1st therapy approved for the most common form of vitiligo. Based on positive results from the Phase 3 Viti-Up trials https://t.co/MMv5LjZclQ

3 Rx are FDA approved for hidradenitis supprativa (secukinumab, adalimumab, bimekizumab). New JAK1i Povorcitinib in STOP-HS1 and STOP-HS2 ph 3 PCTs (608/619 pts). Povo showed HiSCR50 ~42% vs PBO 29% @wk12. AE: acne, pharyngitis https://t.co/n3FJUOjNuo